Dosage Guidelines for Post-exposure Prophylaxis for HIV
AZT (Zidovudine, Retrovir)
Dose: 240 mg/ m2 per dose BID
Available in capsules 100 mg, tablets 200 mg and 300 mg, and syrup 10mg per ML
Common side effects associated with AZT include nausea, headaches, insomnia, muscle aches and general feeling of fatigue. These side effects often improve with continued treatment. The most serious potential side effects are anemia (a decrease in the number of red blood cells) and/or neutropenia (a decrease in the number of white blood cells).
3TC (Lamivudine Epivir)
Dose: Up to 12 years - 4 mg per kg BID (Max 150 mg BID)
Greater than 12 years - 150 mg BID
Available in tablets 150 mg and solution 10 mg per ML
3TC has been tolerated quite well. Potential side effects are generally mild including headache, nausea, diarrhea, abdominal pain and insomnia.
AZT - 3TC (Combivir)
1 tablet BID
Available in tablet combination 300 mg AZT/150 mg 3TC
The most common side effects associated with the use of combivir include headache, nausea and tiredness. Less common side effects include diarrhea, vomiting, decreased appetite, muscle or nerve pain, difficulty sleeping, cough, fever and dizziness. Occasional side effects include stomach pain or cramping, upset stomach, rash, anemia (a decrease in the number of red blood cells), neutropenia (a decrease in the number of white blood cells) and joint pain. A rare side effect is the development of inflammation and enlargement of the liver. Taking Combivir with food will help decrease nausea and headache.
2 does only
Dose 1 - 120 mg/ m2 immediately (maximum 200 mg)
Dose 2 - 120 mg/ m2 48 hours after initial dose
The most common side effects associated with the use of nevirapine are rash, fever and headache. Occasional side effects are nausea, diarrhea, abdominal pain, sores in and around the mouth, numbness and tingling in the arms and legs, muscle pain and hepatitis (inflammation of the liver). Severe and life threatening hepatitis and skin reactions have occurred in a small percentage of patients treated with nevirapine. These two side effects have not been reported with administration of only two doses. Contact the Pediatric Infectious Disease office at any time if a rash is noted. Nevirapine can be taken with or without food.